Studies on the anti-fertility efficacy of Abrime and Embrelin, the compounds of plant origin on mouse testis and uterus

Autor:	Kavya R, Vivekanandan O.S, R. Radhai
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty Uterus Contraceptive drugs Physiology Biology Mouse Testis medicine.anatomical_structure medicine Pharmacology (medical) Abortifacient agent Pharmacology Toxicology and Pharmaceutics (miscellaneous) Abortifacient Carcinogen Anti fertility
Zdroj:	Research Journal of Pharmacy and Technology. 8:369
ISSN:	0974-360X 0974-3618
Popis:	The abortifacient contraceptive drugs (Allopathic) available in the market are regularly taken by women. It may result with many side effects and damage the vital organs, genetic material leading to mutational changes which in-turn prove to be carcinogenic. Abrine and Embelin, the antifertility agents of plant orgin were tested on the uterus, testis, foetuses of mice. The results were indicated that these compounds are toxic to the foetuses, uterus and testis of mice by reducing the spermatozoid production, hypertrophic and haemorrhageic uterus and also anomalies in the morphology and skeletal system of foetuses. The present study revealed that these compounds are also inducing high mutation rate. Hence, these compounds may be used as antifertility or abortifacient agents after further analysis for the safe usage by women as well as men.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5ae39d9cb527679ae1a29f97457affe https://doi.org/10.5958/0974-360x.2015.00062.1 Zobrazit plný text záznamu