Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease
| Autor: | Micheline Njiké-Nakseu, Jean-Baptiste Trabut, Karima Lamouri, Philippe Mathurin, Cosmin Sebastian Voican, Hélène Agostini, Marion Corouge, Sophie Maitre, Alexandre Louvet, Amandine Lebrun, Axel Balian, Sophie Prevot, Sylvie Naveau, Andrea Sanchez, Gabriel Perlemuter, Sébastien Dharancy, Mounia Lachgar |
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| Rok vydání: | 2017 |
| Předmět: |
Alcoholic liver disease
medicine.medical_specialty Cirrhosis Hepatology medicine.diagnostic_test business.industry FibroTest Alcoholic hepatitis medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Fibrosis 030220 oncology & carcinogenesis Liver biopsy Internal medicine medicine 030211 gastroenterology & hepatology business Hepatic fibrosis Transient elastography |
| Zdroj: | Liver International. 37:1697-1705 |
| ISSN: | 1478-3223 |
| Popis: | Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis is insufficiently validated in alcoholic liver disease (ALD). We aimed to validate the diagnostic utility of TE for liver fibrosis in patients with excessive alcohol consumption and evaluate whether Fibrotest® adds diagnostic value relative to or in combination with TE. Methods We conducted a multicentre prospective study on a total of 217 heavy drinkers with high serum aminotransferase levels. Patients underwent liver biopsy, TE, Fibrotest®, PGAA, APRI, FIB-4 and FORNS. The overall diagnostic performance was evaluated by the area under the receiver operating characteristic (AUROC) curves and Obuchowski measures. Results TE values correlated with fibrosis stage (r=.73; P |
| Databáze: | OpenAIRE |
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