ENDOGENOUS ETHANOL PRODUCTION IN A CHILD WITH SHORT BOWEL SYNDROME
| Autor: | Amy S. Fox, Brad D Berman, Jeremy M Drelich, Elinor E Reese |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal tract Ethanol biology business.industry Gut flora Ethanol fermentation Short bowel syndrome medicine.disease biology.organism_classification Gastroenterology Yeast chemistry.chemical_compound chemistry Internal medicine Ampicillin Pediatrics Perinatology and Child Health medicine Fermentation business medicine.drug |
| Zdroj: | Pediatric Research. 18:195A-195A |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Although ethanol occurs naturally as a product of fermentation, there are few reports of significant production in humans. We report a child with ethanol intoxication, apparently caused by alcoholic fermentation within his gastrointestinal tract. A 3 8/12-year-old male with short bowel syndrome on continuous nasogastric (CNG) 3/4-strength Vivonex was admitted for dehydration from gastroenteritis. Otitis media was diagnosed, and the patient was placed on ampicillin. While on nasogastric ampicillin and CNG feedings, the patient developed symptoms of acute ethanol intoxication. Ampicillin was discontinued. Over the following 10 days, blood ethanol rose to 452 mg% before feedings were discontinued. Gastric ethanol (max. 185%) was repeatedly elevated, although less than blood ethanol. Stool ethanol (max. 575 mg%) was greater than blood and gastric ethanol. An extensive search for exogenous ethanol sources was unsuccessful. Stool cultures grew Klebsiella pneumoniae and had a predominance of the yeasts Saccaromyces cerevisiae and Torulopsis glabrata. In vitro studies confirmed the ability of the three organisms to ferment the patient's formula into ethanol. Subsequent feeding did not result in elevations in blood ethanol when stools no longer had yeast overgrowth. Abnormalities of gut anatomy and motility are known to predispose humans to colonization by atypical flora. Fermentation by unusual gut flora can produce near-lethal blood ethanol levels in patients with short bowel syndrome being fed conventional formula. |
| Databáze: | OpenAIRE |
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