ALPHA AND BETA CELL FUNCTION IN CHILDREN WITH JUVENILE AND CHEMICAL DIABETES MELLITUS

Autor:	Anne C. Carter, Salvador Castells, Chhaya Chakrabarti
Rok vydání:	1977
Předmět:	medicine.medical_specialty business.industry Glucagon secretion Alpha (ethology) medicine.disease Glucagon Pathogenesis Endocrinology Basal (medicine) Internal medicine Diabetes mellitus Pediatrics Perinatology and Child Health medicine Juvenile business Hyperinsulinism
Zdroj:	Pediatric Research. 11:512-512
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-197704000-00853
Popis:	Suppression of glucagon secretion by glucose has been suggested as an essential component of normal glucose tolerance. Children with chemical diabetes have abnormal OGTT with hyperin-sulinism (Amer. J. Med. Sci. 271:35, 76). Hypergluconinemia may play a role in the pathogenesis of juvenile diabetes. Thirteen chemical diabetics and 17 normal children had an OGTT (1.75gm/kg) and 20 juvenile diabetics and 8 controls had an oral L-alanine test (200mg/kg). Both tests were performed after an overnight fast, blood samples were drawn at 0, 30, 60, 120 and 180 min. Blood glucose and plasma immunoreactive insulin and glucagon were measured. Chemical diabetics had significant hyperinsulinism at 60' (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b58b9ed0df0db1aa03d96203a4eb7565 https://doi.org/10.1203/00006450-197704000-00853 Zobrazit plný text záznamu