1A and 3D gene sequences of coxsackievirus B3 strain CC: Variation and phylogenetic analysis
| Autor: | Donglai Wu, Fan-Chao Meng, Nihong Liu, Ming-Yu Liu, Qing-Wen Meng |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Genetics
chemistry.chemical_classification Phylogenetic tree Strain (chemistry) Sequence analysis viruses virus diseases Biology musculoskeletal system Biochemistry Amino acid Endocrinology Structural Protein Gene chemistry Coxsackievirus b3 cardiovascular system Nucleotide cardiovascular diseases Molecular Biology Gene |
| Zdroj: | DNA Sequence. 19:8-12 |
| ISSN: | 1042-5179 |
| DOI: | 10.1080/10425170601101428 |
| Popis: | Coxsackievirus B3 (CVB3) was thought to be the most common causative agent of life-threatening viral myocarditis. Coxsackievirus B3 strain CC (CVB3-CC) was isolated in China; however, no sequence data are available. The 1A and 3D regions of CVB3-CC were sequenced and phylogenetic analysis was done with reference to ten other CVB3 strains and all 36 prototype strains of human enterovirus B (HEV-B). Sequence analysis showed that the 1A gene region of CVB3-CC consisted of 207 nucleotides, encoding 69 amino acids; and the 3D gene region was comprised of 1386 nucleotides, encoding 462 amino acids. Variation analysis showed that the 3D gene of CVB3 strain CC varied the least among the two regions. Phylogenetic tree analysis of the 1A and 3D regions indicated that CVB3-CC clustered together with CVB3 Nancy strain suggesting that there may be a close evolutionary relationship between the two strains. Incongruity was observed between the non-structural protein gene and the structural protein gene trees, according ... |
| Databáze: | OpenAIRE |
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