| Popis: |
s / The Breast 24 S3 (2015) S21–S75 S67 Results: The median age of primary breast cancer diagnosis was 53 years (range, 32 to 67). One patient had clinical stage I disease, 6 patients were stage IIA, 5 patients were stage IIB, one patient was stage IIIA. The median interval from primary breast cancer diagnosis to pulmonary metastasis diagnosis was 75 months. The concordance rate of ER status between primary and pulmonary metastatic tumors was 77.1%, PgR status was 62.0%, HER2 status was 100% and there was no negative-to-positive change. The median survival time after pulmonary metastasis of 3 patients who had positive-to-negative in ER status was 16 months. 7 patients of 8 patients who had ER positive in also primary and pulmonary metastatic tumors had started endocrine therapy; the median survival time after pulmonary metastasis of the 7 patients was 54 months. While the median survival time after pulmonary metastasis of the patients with which PgR status accorded was 64 months, the patients with which PgR status discorded was 46 months. Conclusion: The patients who have positive-to-negative in ER status are worse prognosis, and a possibility that an endocrine therapy is invalid is considered. However, the patients who have ER positive in also primary and pulmonary metastatic tumors can continue an endocrine therapy for long time, and obtain a long prognosis. The biopsy of pulmonary metastatic lesion will bring a prognosis prediction and sometimes help the decision of treatment strategy. |
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