Enantioselective synthesis of 2,3-diphenyl-1,4-butanediol via oxidative coupling of phenylacetic acid chiral 1,1′-bi-2-naphthyl ester using TiCl4/Et3N

Autor:	Mariappan Periasamy, Vutukuri Dharma Rao
Rok vydání:	2000
Předmět:	Inorganic Chemistry Acid derivative chemistry.chemical_compound chemistry Reagent Organic Chemistry Enantioselective synthesis Organic chemistry Oxidative coupling of methane Physical and Theoretical Chemistry 1 4-Butanediol Phenylacetic acid Catalysis
Zdroj:	Tetrahedron: Asymmetry. 11:1151-1155
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(00)00040-9
Popis:	Oxidative coupling of phenylacetic acid ester of homochiral 1,1′-bi-2-naphthol 2 was achieved by reaction with TiCl4/Et3N to obtain the corresponding 2,3-diphenylsuccinic acid derivative 3, which on reduction using the NaBH4/I2 reagent gives homochiral 2,3-diphenyl-1,4-butanediol. X-Ray structural analysis was carried out for the compounds (R)-(+)-2 and (R,R,R)-(−)-3.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b57a9ed979e9babe377ce6e33e9b9db9 https://doi.org/10.1016/s0957-4166(00)00040-9 Zobrazit plný text záznamu Full Text from ScienceDirect