ChemInform Abstract: Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-Type Reaction of Oxazolones and Enol Ethers

Autor:	Jetze J. Tepe, Jason S. Fisk, Timothy L. Friebe, Robert A. Mosey
Rok vydání:	2008
Předmět:	Oxazolone chemistry.chemical_classification chemistry.chemical_compound chemistry Intermolecular force Biological activity General Medicine Enol Medicinal chemistry Ene reaction Alkyl
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
Popis:	tert-Alkyl amino hydroxy carboxylic acids are abundantly present within the structure of many biologically active natural products. We describe herein the synthesis of these substrates using an oxazolone-mediated ene-type reaction with enol ethers followed by NaBH4 reduction of the intermediate oxazolone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b579804b31f90f51338689e0890bfbae https://doi.org/10.1002/chin.200831064 Zobrazit plný text záznamu Plný text