ANREDERA CORDIFOLIA LEAVES FRACTION AS AN ANTI-HYPERLIPIDEMIA
| Autor: | Dwintha Lestari |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class Ethyl acetate Pharmaceutical Science Fraction (chemistry) 030226 pharmacology & pharmacy 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animal science Internal medicine Hyperlipidemia medicine Pharmacology (medical) Anredera cordifolia Pharmacology medicine.diagnostic_test biology Triglyceride Chemistry Cholesterol medicine.disease biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Endocrinology lipids (amino acids peptides and proteins) Lipid profile |
| Zdroj: | Asian Journal of Pharmaceutical and Clinical Research. 9:82 |
| ISSN: | 2455-3891 0974-2441 |
| DOI: | 10.22159/ajpcr.2016.v9i6.13628 |
| Popis: | Objective: The objective of this research was to evaluate reduction of blood cholesterol level by fraction extracts of binahong (Anredera cordifolia) o n male Wistar rats. Methods: The rats were given high fat food every day for 3 months and pure cholesterol on week 0, 3, 7 and 11. After that each binahong fraction (n-hexane fraction, ethyl acetate fraction and water fraction) with doses of 50 mg/kg bw, 100 mg/kg bw, 200 mg/kg bw were given orally for 3 weeks and observed for lipid profile on day 21. Results: The result showed that n-hexane, ethyl acetate and water fractions of binahong leaves decreased total cholesterol, triglyceride and LDL level, and did not influence the HDL level. Meanwhile statin decreased total cholesterol, triglyceride and LDL level, and increased HDL level. Conclusion: Ethyl acetate fraction of binahong leaves significantly reduced total cholesterol level, triglycerides, LDL level compared to negative control group (p< 0.05) and had no influence in HDL level. K eywords : Atherosclerosis, Anredera cordifolia, cholesterol |
| Databáze: | OpenAIRE |
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