Qualitative Untersuchung der Hirnmorphologie im CT bei Agoraphobien
| Autor: | J. Gregor, Cornelius Wurthmann, Olaf Effenberger, A. Schwarz, B. Bogerts, W. Döhring, Baumann B |
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| Rok vydání: | 1998 |
| Předmět: |
Temporal cortex
medicine.medical_specialty Third ventricle business.industry Brain morphometry medicine.disease Lateralization of brain function Psychiatry and Mental health Lateral ventricles medicine.anatomical_structure Cerebrospinal fluid Neurology Cortex (anatomy) Internal medicine medicine Cardiology Neurology (clinical) business Agoraphobia |
| Zdroj: | Fortschritte der Neurologie · Psychiatrie. 66:427-431 |
| ISSN: | 1439-3522 0720-4299 |
| DOI: | 10.1055/s-2007-995281 |
| Popis: | This CT study was designed to assess brain morphology in agoraphobia. 21 patients and 21 normal control subjects matched in age and sex were investigated. Frontal and parietooccipital cortex, temporal cortex, lateral ventricles and third ventricle were evaluated by qualitative assessment on a 3-point scale (normal, questionable, abnormal). Patients showed significant bilateral enlargement of prefrontal cortical cerebrospinal fluid (CSF) spaces (p < .05). The rating "abnormal" was given to none (0%) of the normal controls, but to 6 (28.6%) of the patients in the left hemisphere, and to 4 patients (19%) in the right hemisphere, respectively. No qualitative differences were seen in the temporal cortex, lateral ventricles and third ventricle. These findings support the hypothesis that alterations in brain morphology are involved in the etiology of agoraphobia. The lack of a correlation between CSF enlargement and duration of illness suggests that prefrontal CSF enlargement is a neurobiological vulnerability marker in agoraphobia. |
| Databáze: | OpenAIRE |
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