Liver enzyme induction caused by antipyrine
| Autor: | E Kontopoulos, D Koliouskas, K Malaka-Zafiriu |
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| Rok vydání: | 1980 |
| Předmět: | |
| Zdroj: | Pediatric Research. 14:1429-1429 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198012000-00123 |
| Popis: | Among the substances which have an inducing effect on the enzymatic activity of the liver, antipyrine has been lately used therapeutically, in pregnant women in order to prevent neonatal hyperbilirubinemia. In the present paper we determined liver microsomal enzyme activity caused by antipyrine, by studying various hapatic enzyme systems responsible for bilirubin as well as drug metabolism. Twelve (12) volunteers participated in the study, aged 29-36 years. Three hundred (300) mg of antipyrine per day were administered p.o., to each one of them for a period of 10 days. Urinary D-glucaric acid (D-GA) excretion, serum gamma-glutamyl-transpertidase (γ -GT) urinary salicylamide glucuronide formation rate and saliva half-life of antipyrine. No statistically significant difference was observed in serum γ -GT and saliva half-life of antipyrine. On the contrary, a very significant statistical difference (P < 0, 001) was found in urinary D-GA excretion and salicylamide glucuronide formation. The above results show that the administration of antipyrine caused an increase of the hepatic enzyme activity, as far as the enzymes involved in the metabolism of glucuronic acid, as well as those involved in the formation of salicylamide glucuronide are concerned. It is well known these enzyme systems take part in the metabolism of bilirubin. |
| Databáze: | OpenAIRE |
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