Detection of Undiagnosed Elevated Cardiovascular Risk Biomarkers among HIV-Positive Patients on Antiretroviral Therapy (ART) in Kigali-City, Rwanda
| Autor: | Marcus Bushaku, Caleb Nyamwange, Arthur Kwena, Marc Twagirumukiza, Jean Nepo Utumatwishima, Regine Mugeni, Victor Davila-Roman, Aurore Nishimwe, Kenneth Schectman, W Todd Cade, Dominic Reeds, Eugene Mutimura |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Cultural Studies
Pulmonary and Respiratory Medicine History Visual Arts and Performing Arts General Chemical Engineering Strategy and Management General Mathematics General Chemistry Cell Biology Education Cellular and Molecular Neuroscience Philosophy Geophysics Geochemistry and Petrology General Earth and Planetary Sciences Cardiology and Cardiovascular Medicine Law Molecular Biology Social Sciences (miscellaneous) Music General Environmental Science |
| Zdroj: | Journal of AIDS and HIV Treatment. 5:13-21 |
| Popis: | Background: Similar to other African countries, life expectancy of people living with HIV infection has improved due to access to antiretroviral therapy (ART) in Rwanda. However, both HIV infection and use of ART are associated with cardiovascular disease (CVD) risks, due to adverse changes in some biomarkers, causing dyslipidemia and other metabolic imbalances. Biomarkers for CVD risk in HIV-infected individuals taking ART, has not been well characterized in Rwanda. We evaluated the association between the use and duration of ART and biomarkers of CVD risk among HIV infected adults in Rwanda. Methods: A total of 150 participants (18-45 years) from HIV clinics in public Health Center in Kigali included n=30 HIV-uninfected (HIV-) and n=120 HIV-infected (HIV+) adults. Among the HIV+ adults, n=40 participants were ART-naïve. Cross-sectional data were collected on healthrelated behaviors and biochemical markers of CVD risk. We compared CVD-related biomarkers between HIV-, HIV+ ART-naïve, and HIV+ on ART groups. Results: The majority of participants were women (60%) and HIV- were younger (35 ± 6 vs. 31 ± 6 years). Total cholesterol and triglycerides concentrations were associated with ART usage. Serum triglycerides concentrations were lower in HIV+ ART-naïve compared to HIV+ on ART (76.6 ± 38.9 mg/dl vs. 85.0 ± 38.3 mg/dl; p< 0.01). While total cholesterol concentrations were higher in HIV+ on ART than HIV+ ART-naïve (136.0 ± 45.1 mg/dl vs. 130.0 ± 36.5 mg/dl; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|