| Autor: |
Yihan Xu, Zhihua Lv, Xiaofang Lian, Mingming Yu, Cong Wang, Guilin Liu, Zhuo Li |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Revista Brasileira de Farmacognosia. 31:463-469 |
| ISSN: |
1981-528X |
| DOI: |
10.1007/s43450-021-00191-0 |
| Popis: |
A validated and sensitive 1H NMR method was developed for the qualitative and quantitative analysis of the two main components of “xinnaoxin” prescriptions, salidroside and betaine. For the quantitative analysis, the characteristic signals for H-3 and H-5 of salidroside at δ 7.08 ppm (2H, J = 8.58 Hz), as well as the equivalent methyl groups of betaine at δ 3.12 ppm, were selected. The verification of the analytical method was accurate and in conformity with the guidance of the Chinese Pharmacopoeia. Furthermore, it has been applied to the quality assurance of products from different pharmaceutical companies. The results show that the content of salidroside in different products was satisfactory consistent with the results determined by high-performance liquid chromatography. This work implied that 1H NMR represents a feasible alternative to liquid chromatography for quantitation of salidroside and was suitable for the more comprehensive quality control of “xinnaoxin” commercial products by the simultaneous quantification of salidroside and betaine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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