Redox-active metal(II) complexes of sterically hindered phenolic ligands: Antibacterial activity and reduction of cytochrome c. Part II. Metal(II) complexes of o-diphenol derivatives of thioglycolic acid
| Autor: | G. I. Polozov, N.V. Loginova, I.I. Azarko, Anna T. Gres, A.S. Halauko, R.A. Zheldakova, Y. V. Faletrov, T.V. Koval’chuk, N.P. Osipovich, Oleg I. Shadyro, Vladimir M. Shkumatov, Yury S. Halauko |
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| Rok vydání: | 2011 |
| Předmět: |
Steric effects
Cytochrome biology Cytochrome c Inorganic chemistry Inorganic Chemistry Metal Acetic acid chemistry.chemical_compound chemistry visual_art Materials Chemistry visual_art.visual_art_medium biology.protein Density functional theory Thioglycolic acid Physical and Theoretical Chemistry Antibacterial activity Nuclear chemistry |
| Zdroj: | Polyhedron. 30:2581-2591 |
| ISSN: | 0277-5387 |
| Popis: | The synthesis and physico-chemical characterization of Fe(II) and Mn(II) complexes of 2-[4,6-di(tert-butyl)-2,3-dihydroxyphenylsulfanyl]acetic acid (HLI) and 2-[4,6-di(tert-butyl)-2,3-dihydroxyphenylsulfinyl]acetic acid (HLII) were carried out. The investigation of the molecular and electronic structure of Cu(II), Ni(II), Zn(II), Fe(II) and Mn(II) complexes has been performed within the density functional theory (DFT) framework. The computed properties were compared to the experimental ones, and molecular structures of the compounds were proposed based on the array of spectral data and quantum chemical calculations. Antibacterial activity of the Fe(II) and Mn(II) complexes was evaluated in comparison with Cu(II), Co(II), Ni(II) and Zn(II) complexes and three standard antibiotics; it was found to follow the order: (1) Сu(LI)2 > Mn(LI)2 > HLI > Ni(LI)2 > Zn(LI)2 > Fe(LI)2 > Co(H2O)2LI; (2) Cu(LII)2 > Сo(LII)2 > Ni(LII)2 > Mn(H2O)2(LII)2 > Fe(LII)2 > HLII > Zn(LII)2; their reducing ability (determined electrochemically) followed the same order. Spectrophotometric investigation was carried out in order to estimate the rate of the reduction of bovine heart сytochrome c with the ligands and their metal(II) complexes. The complexes Сu(LI)2, Mn(LI)2 and Co(LII)2 with the high reducing ability were found to be characterized by the highest rates of Cyt с reduction. NADPH:cytochrome P450-reductase had no substantial effect on the rate of сytochrome c reduction with HLI and HLII ligands. |
| Databáze: | OpenAIRE |
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