Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals
| Autor: | Mohd Urooj, Gulam Mohammed Husain, Mahe Alam, Munawwar Husain Kazmi, Mohd. Nadeem, Mohammed Abdul Rasheed Naikodi |
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| Rok vydání: | 2020 |
| Předmět: |
Phenytoin
Modern medicine Clonic Convulsion business.industry medicine.medical_treatment 02 engineering and technology General Medicine Pharmacology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Imipramine 03 medical and health sciences 0302 clinical medicine Anticonvulsant Convulsion medicine medicine.symptom 0210 nano-technology business Diazepam medicine.drug Behavioural despair test |
| Zdroj: | International Journal of Pharmaceutical Investigation. 10:396-401 |
| ISSN: | 2230-9713 2230-973X |
| DOI: | 10.5530/ijpi.2020.3.70 |
| Popis: | Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extract in experimental animals. Methods: Anticonvulsant activity was tested using maximal electroshock induced convulsion in male sprague dawley rats using diazepam 3 mg/kg, p.o. as positive control. Pentylenetetrazole induced convulsion in swiss male albino mice was performed using phenytoin 25 mg/kg i.p. as positive control. The antidepressant activity of MN was evaluated using forced swim test model in male using Imipramine 20 mg/kg, p.o. as positive control. Results: Antiepileptic study data showed reduction of all parameters like, tonic hind limb extension, clonic convulsion and stupor; however the values were not found statistically significant at all tested dose levels. The results of forced swim test model indicated that majoon najah effectively showed significant (P |
| Databáze: | OpenAIRE |
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