Particle Retention in Airways by Surfactant
| Autor: | Peter Gehr, V Im Hof, Marianne Geiser, Y. Berthiaume, Samuel Schürch |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Chemistry respiratory system engineering.material respiratory tract diseases Deposition (aerosol physics) Pulmonary surfactant Coating Airway wall Conducting airways medicine engineering Biophysics Particle Pharmacology (medical) |
| Zdroj: | Journal of Aerosol Medicine. 3:27-43 |
| ISSN: | 1557-9026 0894-2684 |
| DOI: | 10.1089/jam.1990.3.27 |
| Popis: | With each breath thousands of particles may enter the lungs where they are deposited. They may be retained for various periods of time in the conducting airways, before being removed. The deposition of particles is, by definition, terminated, as soon as the particles touch the airway wall. Following deposition, retention and clearance begin. For both mechanisms structure and surface properties of the coating of the airway wall are important. In some recent studies it has been reported that clearance from the conducting airways may take longer than the postulated 24 hours. Our own recent structural studies with hamster lungs showed that a considerable number of particles initially deposited in the conducting airways of the lungs can be found retained in the airways in close association with the epithelium. These particles were coated with an osmiophilic film owing to phospholipids related to surfactant. This film may be responsible for the displacement of particles from the air to the aqueous (gel... |
| Databáze: | OpenAIRE |
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