Synthesis and Pharmacological Activity of C(2)-Substituted Benzimidazoles

Autor:	K. T. Sultanova, Ya. V. Agatsarskaya, D. V. Mal’tsev, A. S. Taran, M. V. Miroshnikov, A. A. Brigadirova, V. I. Kornilov, D. S. Yakovlev, Anatolii S. Morkovnik, O. N. Zhukovskaya, V. A. Babkova, Alexander A. Spasov, V. A. Anisimova, V. A. Kosolapov
Rok vydání:	2019
Předmět:	Pharmacology 010404 medicinal & biomolecular chemistry Antioxidant 010405 organic chemistry Chemistry medicine.medical_treatment Drug Discovery Pharmacology toxicology medicine Organic chemistry Biological activity 01 natural sciences 0104 chemical sciences
Zdroj:	Pharmaceutical Chemistry Journal. 53:201-206
ISSN:	1573-9031 0091-150X
Popis:	Series of new compounds containing 2-pyrrolidinomethyl and 2-piperazinomethyl groups and 2-morpholino and 2-morpholinoethylamine substituents were synthesized. The antiglycation activities of 2-(morpholin-4-yl)-1-(propen-2-en-1-yl)-1H-benzimidazole and 2-(morpholin-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole were comparable to that of aminoguanidine. Some compounds exhibited moderate antiserotonin, anti-angiotensin, antioxidant, and dipeptidyl peptidase-4 (DPP-4) inhibitory effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b55913801e456d3cf0b0c39d9d1a1cf6 https://doi.org/10.1007/s11094-019-01979-0 Zobrazit plný text záznamu Full text from SpringerLink