BONE MINERAL CONTENT AND LINEAR GROWTH IN INFANTS TREATED WITH DEIAMETHASONE FOR BRONCHOPULMONARY DYSPLASIA
| Autor: | Gopi Menon, Jeremy R Williams, Brada Mcloughlin, Fauzia Davidson, Nail Mcintosh |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Bone mineral
medicine.medical_specialty business.industry Urology medicine.disease Postnatal age medicine.anatomical_structure Endocrinology Forearm Bronchopulmonary dysplasia Internal medicine Pediatrics Perinatology and Child Health medicine Mann–Whitney U test Gestation business Linear growth Dexamethasone medicine.drug |
| Zdroj: | Pediatric Research. 35:276-276 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199402000-00128 |
| Popis: | Introduction Prolonged therapeutic use of adrenal glucocorticoids reduces bona mineral content (BMC) and retards linear growth in children. This study aimed to assess these effects in infants with bronchopulmonary dysplasia (BPD) treated with dexamethasone. Methods 15 treated infants (group A, median [range] gestation 27 (26-29) weeks, were compared with 15 other infants with BPD (group B, median [range] gestation 27.5 [25-31]). BMC of the radius waa measured using dual energy Xray absorptiometry, and forearm length (FAL) using a vernier caliper. Treated infants were measured weekly when possible for the 4 weeks before, during and 4 weeks after treatment and controls at equivalent postnatal age. Median (range) age of starting dexamethasone was 30 (15-55) days, stopping 65 (42-88) days. Results Pretreatment median (range) values were: for BMC (mg/mm) A: 1.51 (0.98-3.18), B: 1.65(1.27-1.B8) and for FAL (mm) A: 50.9(40.6-68.3), B: 49.6(42.0-67.1). Subsequent values were expressed as a change from immediate pretreatment values (dBMC and dFAL). Groups were compared using the Mann Whitney U test. BMC and FAL increased overall during the treatment period. There was no difference in dBMC between groups at any stage. There was an increasing difference in dFAL between groups. Median values (range) immediately following treatment (dBMC in mg/mm and dFAL in mm) were: Conclusion Dexamethasone has no measurable immediate effect on bone mineral accretion in infants with BPD but there is a trend to slowing of linear forearm growth. |
| Databáze: | OpenAIRE |
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