The effects of Verapamil in potentiating the action of Doxorubicin in recently derived pancreatic carcinoma cell lines

Autor:	M. O. Symes, D. Alderson, Teresa Lai, C. M. P. Collins
Rok vydání:	1991
Předmět:	Quinidine Multiple drug resistance Chemistry Cell culture Cyclosporin a medicine Verapamil Doxorubicin Efflux Pharmacology Receptor medicine.drug
Zdroj:	Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy ISBN: 9782817807843
DOI:	10.1007/978-2-8178-0782-9_54
Popis:	Multidrug resistance (MDR) to a variety of anti-cancer drugs may be exhibited by tumour cells expressing the MDRI gene product P170 glycoprotein [1, 2]. A number of agents, eg Verapamil, Quinidine and Cyclosporin A, compete with P170 for receptors on the plasma membrane vesicles active in drug transport and thus inhibit drug efflux from cells [3].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5446fa5fb76aa7f9d913302e27aec08 https://doi.org/10.1007/978-2-8178-0782-9_54 Zobrazit plný text záznamu