Increased serum nonesterified fatty acid and low ionised calcium concentrations are associated withpost partumcolic in mares
| Autor: | Susan J. Holcombe, S. E. Wismer, K. A. Kurtz, John B. Kaneene, H. A. Roessner, Raymond J. Geor, R. M. Embertson |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 040301 veterinary sciences animal diseases digestive system 0403 veterinary science 03 medical and health sciences NEFA Animal science Internal medicine medicine reproductive and urinary physiology Dairy cattle chemistry.chemical_classification Pregnancy business.industry Fatty acid Horse Repeated measures design 04 agricultural and veterinary sciences General Medicine Odds ratio medicine.disease female genital diseases and pregnancy complications Confidence interval 030104 developmental biology Endocrinology chemistry business |
| Zdroj: | Equine Veterinary Journal. 48:39-44 |
| ISSN: | 0425-1644 |
| DOI: | 10.1111/evj.12391 |
| Popis: | Summary Reasons for performing study Increased serum nonesterified fatty acids (NEFA) and decreased serum electrolytes are linked to abdomasal displacements in post partum dairy cattle. Post partum colic in mares may be associated with metabolic changes specific to pregnancy and the periparturient period. Objectives To determine if fluctuations in serum NEFA, ionised calcium (iCa) and magnesium (iMg) occurred in periparturient mares and if these alterations were associated with post partum colic. Study design Longitudinal observational study. Methods Mares from 3 farms in central Kentucky were enrolled. Blood samples were collected 14 days prior to the estimated foaling date, within 4 days post parturition, and 14 and 28 days after foaling for batch analysis of serum NEFA, iCa and iMg. Health information was provided by farm managers and veterinarians. Data were analysed using Kruskal–Wallis χ2 statistic for nonparametric data and a matched case/control approach. Repeated measures logistic regression models were developed. Results Serum NEFAs were higher at 14–1 day before foaling (mean ± s.d., mmol/l), 0.28 ± 0.12, P = 0.04 and from foaling to 4 days after foaling, 0.29 ± 0.20 (P = 0.05) in mares that developed colic compared with those that did not colic, 0.19 ± 0.05 and 0.21 ± 0.14, respectively. Ionised calcium was lower at 15–28 days post foaling in mares that showed colic, 1.50 ± 0.17 compared to mares that did not colic, 1.60 ± 0.12, P = 0.02. Risk of colic in post partum mares increased 38% for each 0.1 mmol/l increase in serum NEFA (odds ratio = 1.38, 95% confidence interval 1.06–1.81, P = 0.02). Conclusions Mares with post partum colic had significantly higher serum NEFA and lower iCa prior to the colic episode compared with mares that did not develop colic. Monitoring these metabolic alterations may lead to predictive and preventive colic strategies for post partum mares. |
| Databáze: | OpenAIRE |
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