Inhibitory action of McN-A-343 on acetylcholine-induced contraction in molluscan smooth muscle
| Autor: | Murakami Hajime, Kizawa Yasuo, Kusama Tadashi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
medicine.medical_specialty Carbachol Immunology Muscarinic acetylcholine receptor M1 Biology Muscarinic agonist chemistry.chemical_compound Nicotinic agonist Endocrinology chemistry Internal medicine medicine Cholinergic Hexamethonium medicine.symptom Acetylcholine Muscle contraction medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 102:489-493 |
| ISSN: | 0306-4492 |
| DOI: | 10.1016/0742-8413(92)90148-z |
| Popis: | 1. The effect of McN-A-343 (McN) on the contractile response to certain cholinergic agonists was investigated in the anterior byssus retractor muscle (ABRM) of Mytilus . 2. McN (3 × 10 −5 to 3 × 10 −4 M) dose-dependently inhibited the contractile response to acetylcholine (ACh), carbachol (CCh) and 1,1-dimethyl-4-phenyl-piperazinium (DMPP) in a noncompetitive manner. 3. McN (3 × 10 −5 to 3 × 10 −4 M) did not have any effect on the contractile response to KCl, caffeine or FMRF-NH 2 . 4. In the rectus abdominis muscle (RAM) of frog, McN produced a contractile response similar in potency to that produced by ACh, CCh and DMPP. 5. In the RAM, hexamethonium (C 6 ) (3 × 10 −4 M) and d-tubocurarine (d-Tc) (3 × 10 −6 M) inhibited the contractile response to McN in a noncompetitive manner, and to CCh and DMPP in a competitive manner. 6. These findings indicate that McN, a selective M 1 muscarinic agonist in mammalian tissues, acts as a nicotinic agonist in the RAM, and as a cholinergic antagonist in the ABRM. |
| Databáze: | OpenAIRE |
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