Targeting accuracy of transcranial magnetic resonance–guided high-intensity focused ultrasound brain therapy: a fresh cadaver model
Autor: | Najat Salameh, Luc Darrasse, Jean-François Aubry, Dorian Chauvet, Rémy Guillevin, Anne-Laure Boch, Mathias Fink, Line Souris, Mickael Tanter, Mathieu Pernot, Laurent Marsac |
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Rok vydání: | 2013 |
Předmět: |
medicine.medical_specialty
Proton resonance frequency Essential tremor medicine.diagnostic_test business.industry medicine.medical_treatment Magnetic resonance imaging medicine.disease High-intensity focused ultrasound Focused ultrasound Surgery Fresh cadaver medicine Thalamic nucleus Ultrasonic sensor business Nuclear medicine |
Zdroj: | Journal of Neurosurgery. 118:1046-1052 |
ISSN: | 1933-0693 0022-3085 |
DOI: | 10.3171/2013.1.jns12559 |
Popis: | Object This work aimed at evaluating the accuracy of MR-guided high-intensity focused ultrasound (MRgHIFU) brain therapy in human cadaver heads. Methods Eighteen heads of fresh human cadavers were removed with a dedicated protocol preventing intracerebral air penetration. The MR images allowed determination of the ultrasonic target: a part of the thalamic nucleus ventralis intermedius implicated in essential tremor. Osseous aberrations were corrected with simulation-based time reversal by using CT data from the heads. The ultrasonic session was performed with a 512-element phased-array transducer system operating at 1 MHz under stereotactic conditions with thermometric real-time MR monitoring performed using a 1.5-T imager. Results Dissection, imaging, targeting, and planning have validated the feasibility of this human cadaver model. The average temperature elevation measured by proton resonance frequency shift was 7.9°C ± 3°C. Based on MRI data, the accuracy of MRgHIFU is 0.4 ± 1 mm along the right/left axis, 0.7 ± 1.2 mm along the dorsal/ventral axis, and 0.5 ± 2.4 mm in the rostral/caudal axis. Conclusions Despite its limits (temperature, vascularization), the human cadaver model is effective for studying the accuracy of MRgHIFU brain therapy. With the 1-MHz system investigated here, there is millimetric accuracy. |
Databáze: | OpenAIRE |
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