LIPOPHILICITY CHARACTERIZATION BY REVERSED-PHASE HPLC OF POTENTIAL ANTITUBERCULOTICS

Autor:	Jiri Klimes, Vera Klimesova, Petr Kastner, Petra Velenovska
Rok vydání:	2002
Předmět:	Chromatography Nitrile Chemistry Clinical Biochemistry Analytical chemistry Pharmaceutical Science Reversed-phase chromatography Antituberculous drugs Biochemistry High-performance liquid chromatography Analytical Chemistry chemistry.chemical_compound Stationary phase Phase (matter) Lipophilicity Antibacterial agent
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 25:2849-2856
ISSN:	1520-572X 1082-6076
Popis:	Lipophilicity is one of the properties which influence the partition of a substance in biological media. The reversed-phase high-performance liquid chromatographic (RP-HPLC) capacity factors k of two series of 2-benzylthioderivatives, newly synthesized as potential antituberculous drugs, were determined on a C-18 stationary phase with methanol–water as the mobile phase, using UV detection. The measured log k values were compared with the log P values obtained by means of a mathematical method. High correlation was found between log P and log k values.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b514f5863a2a32386ced7015f285e906 https://doi.org/10.1081/jlc-120014954 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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