Trimesic acid is a suitable building block in triple four-component Ugi reaction: access to unique trivalent compounds

Autor:	Negin Dehghan, Hossein Nasr-Isfahani, Afshin Sarvary, Mohammad Bakherad
Rok vydání:	2020
Předmět:	chemistry.chemical_classification 010405 organic chemistry Isocyanide Peptide General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Aldehyde 0104 chemical sciences chemistry.chemical_compound chemistry Reagent Dendrimer Ugi reaction Amine gas treating Trimesic acid
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 151:397-404
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-020-02554-0
Popis:	A triple four-component Ugi reaction of isocyanide, amine, aldehyde, and trimesic acid as the acid component with three acidic functional groups in MeOH at 65 °C has been disclosed. The process employs readily available and low-cost reagents, a convenient synthetic procedure, and mild reaction conditions for the synthesis of pharmacologically significant and structurally interesting compounds with several peptide groups, suitable for dendrimers and self-assembling. Substituents could be independently varied at three different positions. The structural assignments are supported by 1H and 13C NMR data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5125e19bc46659b25c31e3e0d2c093c https://doi.org/10.1007/s00706-020-02554-0 Zobrazit plný text záznamu Full text from SpringerLink