The crude extract ofCorni Fructusinhibits the migration and invasion of U-2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling
| Autor: | Jaung Geng Lin, Shu Chun Hsu, Jin-Cherng Lien, Yi Ping Huang, Ju Hwa Lin, Jing Gung Chung, Fu Shin Chueh, Ching Lung Liao, Ping Ping Wu, Chien Chih Yu |
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| Rok vydání: | 2013 |
| Předmět: |
Matrix metalloproteinase inhibitor
Chemistry Health Toxicology and Mutagenesis General Medicine Management Monitoring Policy and Law Matrix metalloproteinase Toxicology NFKB1 medicine.disease Cell culture Cancer cell Immunology Cancer research medicine Osteosarcoma PI3K/AKT/mTOR pathway Protein kinase C |
| Zdroj: | Environmental Toxicology. 30:53-63 |
| ISSN: | 1520-4081 |
| DOI: | 10.1002/tox.21894 |
| Popis: | Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U-2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U-2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF-κB p65, COX-2, HIF-1α, PI3K, Rho A, ROCK-1, IRE-1α, p-JNK1/2, p-ERK1/2, p-p38, Ras, p-PERK, MMP-2, MMP-9, and VEGF in U-2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells. |
| Databáze: | OpenAIRE |
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