Bimodal Fluorescent and Magnetic Nanoparticles Based on Carbon Quantum Dots and Metal-Carbon Nanocomposites for Bio-Applications
| Autor: | Artem Minin, Ilya Byzov, Mikhail Uimin, Anatoly Ye. Ermakov, Nina Shchegoleva, Sergey Zhakov, Leonid Smoluk, Maria Ulitko |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Materials science Silicon dioxide Physics::Optics Nanoparticle Nanotechnology law.invention Metal 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Confocal microscopy law General Materials Science Nanocomposite Mechanical Engineering equipment and supplies Fluorescence 030104 developmental biology Magnetic hyperthermia chemistry Mechanics of Materials visual_art visual_art.visual_art_medium Magnetic nanoparticles human activities 030217 neurology & neurosurgery |
| Zdroj: | Key Engineering Materials. 683:454-461 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.683.454 |
| Popis: | The simultaneous combination of optical and magnetic properties of nanoparticles would greatly benefit in vivo disease diagnosis as well as in situ monitoring of cell in cell culture. The most promising application of magnetic particles in biomedicine is MRI contrast enhancement and magnetic hyperthermia. Another important thing is the determination of exact localization of nanoparticles in the cell culture that can be defined by e.g. optical way. In our investigation we used the iron nanoparticles encapsulated in carbon as a magnetic component and carbon quantum dots as an optical labels to provide the photostability and fluorescence in a wide range of wavelengths. In order to avoid the fluorescence quenching in bimodal particles the optical and magnetic components should be separated by insulator layer. To create the optimal bimodal nanoparticles for this purpose the non-typical configuration of nanocomposites was realized, namely, a fluorescent core was separated from the coated magnetic particles by silicon dioxide matrix. Finally, it was shown that these bimodal nanocomposites demonstrate the high magnetic properties, good visualized ability and low toxicity for living cells as well. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|