Efficient Preparation of New Rhodium- and Iridium-[Bis(oxazolinyl)-3,5-dimethylphenyl] Complexes by CH Bond Activation: Applications in Asymmetric Synthesis

Autor:	Jun-ichi Ito, Hisao Nishiyama, Takushi Shiomi
Rok vydání:	2006
Předmět:	Acrylate Enantioselective synthesis chemistry.chemical_element General Chemistry Medicinal chemistry Rhodium Catalysis Benzaldehyde chemistry.chemical_compound chemistry Aldol reaction Organic chemistry Iridium Conjugate
Zdroj:	Advanced Synthesis & Catalysis. 348:1235-1240
ISSN:	1615-4169 1615-4150
DOI:	10.1002/adsc.200606049
Popis:	The bis(oxazolinyl)-3,5-dimethylphenylrhodium and -iridium complexes were synthesized in high yields by an efficient C-H bond activation method with 4,6-dimethyl-1,3-bis(oxazolinyl)benzene derivatives. The catalytic activity of the complexes was examined for the asymmetric conjugate reduction of (E)-ethyl 3-phenylbut-2-enoate and the asymmetric reductive aldol reaction of tert-butyl acrylate and benzaldehyde. It was found that the rhodium complex of 3,5-dmPhebox showed the higher catalytic activity, whereas the corresponding iridium complexes proved to be less active.
Databáze:	OpenAIRE
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