Phospholipase A2 Inhibitors from an Erythrina Species from Samoa
| Autor: | Vinod R. Hegde, Ping Dai, Mahesh Patel, Pradip R. Das, M. S. Puar, Robert W. Bryant, Jin-Keon Pai, P. A. Cox |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Phospholipase A biology Chemistry Stereochemistry Organic Chemistry Flavonoid Pharmaceutical Science Pharmacognosy Antimicrobial biology.organism_classification Analytical Chemistry Phospholipase A2 Enzyme Complementary and alternative medicine visual_art Drug Discovery visual_art.visual_art_medium biology.protein Molecular Medicine Bark Erythrina |
| Zdroj: | Journal of Natural Products. 60:537-539 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np960533e |
| Popis: | Three flavonoid phospholipase A 2 (PLA 2 ) inhibitors were isolated from a MeOH extract of the bark of the Samoan medicinal plant Erythrina variegata. Two of these compounds, 4'-hydroxy-3',5'-diprenylisoflavonone (abyssinone V) (1) and 3,9-dihydroxy-2,10-diprenylpterocarp-6a-ene (erycrystagallin) (3), have been previously reported as antimicrobial agents from plants belonging to other Erythrina species. The isoflavonone 4'-hydroxy-6,3',5'-triprenylisoflavonone (2) is a new compound, and its structure was determined by spectroscopic techniques. The IC 50 values for the PLA 2 enzyme were 6, 10, and 3 μM for 1-3, respectively. |
| Databáze: | OpenAIRE |
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