Abstract P071: Mineralocorticoid Receptor Overexpression in Adipose Tissue Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase PTGDS and lipocalin-2 NGAL
| Autor: | Alessandra Feraco, Riccardo Urbanet, Aurelie Nguyen Dinh Cat, Nicolas Venteclef, Soumaya El Mogrhabi, Patrick Rossignol, Francesco Fallo, Rhian M Touyz, Frederic Jaisser |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Hypertension. 66 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hyp.66.suppl_1.p071 |
| Popis: | Objectives: Metabolic Syndrome (MetS) is a cluster of metabolic risk factors associated with a higher risk for cardiovascular events. Adipose tissue (AT) plays a central role in the obesity-related metabolic abnormalities and it’s known that Mineralocorticoid Receptor (MR) activation affects adipocyte differentiation and function. The purposes of this study were to evaluate the molecular and metabolic consequences of adipocyte-targeted increase in MR expression in mice. Results: In our study we showed that MR expression is increased in visceral adipose tissue (VAT) in a preclinical mouse model of MetS. Thus, we generated a double transgenic mouse model with a conditional and inducible overexpression of MR in AT (Adipo-MORE), demonstrating that increased expression of MR in AT contributes to MetS development with multiple metabolic abnormalities, including visceral obesity (VAT mass, control-MR 5.0±0.6 adipo-MORE 10.4±1.8, p Conclusions: We demonstrated that PTGDS is a novel direct MR target in rodent adipocytes mediating adipogenic effects of MR activation. We also found that NGAL is induced in presence of MR overexpression in adipocytes in vivo and ex vivo. In consideration of our results, other analyses are necessary to better understand the role of NGAL as adipocyte MR target. |
| Databáze: | OpenAIRE |
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