SPONTANEOUS OVARIAN CHORIOCARCINOMA IN TWO B6C3F1 MICE

Autor:	Masashi Yasuba, Kaoru Toyosawa, Kazuo Okimoto, Emi Kikawa, Takatoshi Koujitani
Rok vydání:	1995
Předmět:	medicine.medical_specialty Pathology Choriocarcinoma Ovary Biology Toxicology medicine.disease Pathology and Forensic Medicine Basophilic Ovarian Choriocarcinoma Human placental lactogen Endocrinology medicine.anatomical_structure Cytoplasm Giant cell Internal medicine medicine Neoplasm
Zdroj:	Journal of Toxicologic Pathology. 8:435-439
ISSN:	1881-915X 0914-9198
DOI:	10.1293/tox.8.435
Popis:	This paper describes spontaneous ovarian choriocarcinoma in two B6C3F1 mice used in toxicity studies. One animal (case 1) was sacrificed at eight weeks of age, and the other one (case 2) was found dead at sixty-seven weeks of age. Macroscopically, a dark red dot measuring approximately I mm in diameter (case 1) and hematoma-like enlargement (case 2) were observed in the ovary. Microscopically, in case I, the neoplasm was fully packed with tumor cells and erythrocytes. The tumor cells were round to oval giant cells with abundant, faintly basophilic cytoplasm containing PAS positive granules. In case 2, some small and two large hematocysts were present. The hematocysts contained a large number of erythrocytes and a small number of tumor cells. The tumor cells were oval to elongated giant cells with abundant, basophilic cytoplasm. Immunohistochemically, tumor cells in both cases were positive or weakly positive for human placental lactogen (HPL), human chorionic gonadotrophin (HCG), and human specific beta-1 glycoprotein (SP-1). Both cases were considered to be originated from germ cells since those female animals were virgin.
Databáze:	OpenAIRE
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