A One-Pot and Efficient Preparation of (S)-Benzyl 4-Hydroxy-2-Pentynoate from (S)-n-Butyn-2-Ol Using an Unusual Lithiation with n-BuLi and a Catalytic Amount of Hexamethyldisilazane

Autor:	Cesar Colon, Gaifa Lai
Rok vydání:	1999
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Organic chemistry Catalysis Silyl ether
Zdroj:	Synthetic Communications. 29:3011-3016
ISSN:	1532-2432 0039-7911
Popis:	A one-pot, four-step procedure was developed for the efficient preparation of (S)-benzyl 4-hydroxy-2-pentynoate (1) from (S)-3-butyn-2-ol (2), which involved as a key step the unusual lithiation of the silyl ether 5 with n-BuLi in the presence of a catalytic amount of hexamethyldisilazane (HMDS).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b4e3f7bb912d7ba0b7667eb9c21233f4 https://doi.org/10.1080/00397919908086476 Zobrazit plný text záznamu