PERBANDINGAN INHIBISI BRUSEIN D TERHADAP PROTEIN NFKB PADA SEL KANKER PANKREAS SECARA FLEKSIBEL DAN RIGID DOCKING

Autor:	Harry Noviardi, Armi Wulanawati, Sekolah Tinggi Teknologi Industri dan Farmasi Bogor, Muhammad Sholehuddin malik Ibrohim
Rok vydání:	2017
Předmět:	Bruceine D Docking (molecular) Chemistry Pancreatic cancer medicine Cancer research medicine.disease Chemoradiotherapy Gemcitabine medicine.drug
Zdroj:	Jurnal Farmamedika (Pharmamedica Journal). 2:55-62
ISSN:	2686-4487 2502-6011
DOI:	10.47219/ath.v2i2.34
Popis:	Pancreatic cancer is a malignant tumor types are particularly deadly. Patients with pancreatic cancer are generally treated with chemoradiotherapy and gemcitabine, but still provide a good clinical outcome. This study aims to determine the ratio of the potential of bruceine D as inhibitors of protein NFĸB transcription of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions are flexible and rigid docking. Based on the analysis docking, docking flexibly deliver better results than rigid. Additionally, bruceine D provides the potential for better inhibition than gemcitabine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b4e3e82cef43a691aec0e76e2a5868fd https://doi.org/10.47219/ath.v2i2.34 Zobrazit plný text záznamu