High prevalence of hyperhomocysteinemia in critically ill patients: Vascular damage and adequate vitamin intake
| Autor: | J. Abilés, Rocio Pérez Abúd, Gonzalo Moratalla, Rosario Moreno-Torres Herrera, Elena Pozo, Antonio Pérez de la Cruz, Manuel Rodríguez Elvira, José Castaño |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Vitamin
medicine.medical_specialty Hyperhomocysteinemia APACHE II Homocysteine business.industry Endocrinology Diabetes and Metabolism medicine.disease_cause medicine.disease Gastroenterology Diet Records Systemic inflammatory response syndrome Clinical trial chemistry.chemical_compound chemistry Internal medicine medicine business Intensive care medicine Oxidative stress |
| Zdroj: | e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 3:e240-e245 |
| ISSN: | 1751-4991 |
| DOI: | 10.1016/j.eclnm.2008.06.011 |
| Popis: | Summary Aims To determine the prevalence of hyperhomocysteinaemia in critically ill patients and its relationship with endothelial damage and vitamin intake. Methods Total antioxidant capacity, lipid peroxides, and carbonyl group in plasma were measured by spectrophotometry. Homocysteine, D-dimer, B12 vitamin and folic acid levels were determined by immunoassay. Daily diet records were compared with vitamin recommendations in 40 consecutive critically ill patients. Results Homocysteinaemia on day 7 was higher in patients with 12 and folic acid than in patients with higher intakes (16.3 ± 3.1 μm/L vs. 9.3 ± 54 μm/L, p r 2 = 0.65, p r 2 = 0.58, p r 2 = −0.57, p r 2 = 0.47, p Conclusions The present findings appear to support the maintenance of an adequate vitamin intake in critically ill patients to reduce their risk of hyperhomocysteinemia, and therefore microthromboses. However, controlled clinical trials are required to establish any causal relationships. |
| Databáze: | OpenAIRE |
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