A Combination Drug Treatment Against Ocular Sulfur Mustard Injury
| Autor: | Richard E. Sweeney, Michael C. Babin, Robyn B. Lee, Karen M. Ricketts, Michele Y. Gazaway, John J. Brozetti |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Chemotherapy
Triamcinolone acetonide business.industry Health Toxicology and Mutagenesis medicine.medical_treatment Cefazolin Sulfur mustard Pharmacology Toxicology Ophthalmology chemistry.chemical_compound chemistry Anesthesia Toxicity Prednisolone medicine business Saline medicine.drug Combination drug |
| Zdroj: | Journal of Toxicology: Cutaneous and Ocular Toxicology. 23:65-75 |
| ISSN: | 0731-3829 |
| DOI: | 10.1081/cus-120027483 |
| Popis: | The eye is considered to be one of the most sensitive organs to sulfur mustard [bis(2‐chloroethyl) sulfide (SM)], with injuries ranging from mild conjunctivitis to advanced corneal disease. Even mild ocular involvement from sulfur mustard exposure can result in both physical and psychological incapacitation. In this study we explored the use of Food and Drug Administration (FDA) approved medications (prednisolone acetate ophthalmic suspension, triamcinolone, and cefazolin) as ocular treatments for sulfur mustard injury. Female New Zealand White rabbits were divided into a SM positive control group (n = 8) and a single treatment group (n = 7). At 10, 20, 30, 60, 90, and 120 min after SM exposure, two drops of prednisolone acetate ophthalmic suspension was administered to each treatment group rabbit while the control group received saline drops. At 120 min after SM exposure, each treatment group animal received a single 1.0 mL sub‐Tenon's injection containing 20 mg triamcinolone and 50 mg cefazolin. Control... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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