Evaluation of major histocompatibility complex class I expression in clear cell renal cell carcinoma as a prognostic tool

Autor:	Adeboya O. Osunkoya, Haydn T. Kissick, Kenneth Ogan, Brian Pollack, Viraj A. Master, Dattatraya Patil, Claire de la Calle, Jonathan Huang, Sarah A. Holzman, Umer Sheikh
Rok vydání:	2015
Předmět:	Cancer Research Pathology medicine.medical_specialty biology business.industry medicine.medical_treatment Major histocompatibility complex medicine.disease Nephrectomy Clear cell renal cell carcinoma Oncology medicine biology.protein business
Zdroj:	Journal of Clinical Oncology. 33:469-469
ISSN:	1527-7755 0732-183X
Popis:	469 Background: After nephrectomy for clear cell renal cell carcinoma (ccRCC) approximately one-third of patients develop metastases. Yet, with currently used prognostic tools such as the TNM staging and the Fuhrman nuclear grade (FNG) system, it is difficult to accurately assess prognosis for each patient. Here, we evaluated Major Histocompatibility Complex Class I (MHCI) expression as a potential prognostic immune marker in ccRCC. Methods: Fifty-five post-nephrectomy patients that presented with localized ccRCC were included. All patients had four or more years of follow up. MHCI was stained in the tumor sections via immunohistochemistry. Then, via an automated image analysis algorithm MHCI expression was quantitated with the Positivity score, the ratio of positively stained pixels over the total number of pixels. Results: Mean MHCI positivity score of the cohort was 0.75 (SE= ±0.20). At the end of the follow-up period, the patients who were alive had higher MHCI expression (0.80 positivity score; SE ±0.14) than those who died of disease (0.62 positivity score; SE= ±0.16; t test, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b4d64f1f2caaa0277ef3b44d9408affc https://doi.org/10.1200/jco.2015.33.7_suppl.469 Zobrazit plný text záznamu