The simulation of multiphase flow field in implantable blood pump and analysis of hemolytic capability
| Autor: | Huimin Fan, Liang Ye, Fang-wen Hong, Tie-yan Li, Deng-cheng Liu, Zhong-min Liu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Materials science
medicine.diagnostic_test Mechanical Engineering Multiphase flow Flow (psychology) Thermodynamics Hematocrit Condensed Matter Physics medicine.disease Hemolysis Blood pump Impeller Axial compressor Mechanics of Materials Modeling and Simulation medicine Shear stress Biomedical engineering |
| Zdroj: | Journal of Hydrodynamics. 25:606-615 |
| ISSN: | 1878-0342 1001-6058 |
| Popis: | The numerical simulation of the axial flow impeller blood pump NIVADIII is carried out by using a CFD multiphase flow model. The hydrodynamic performance of the pump and the flow field in the pump are analyzed, and the shear stress distribution is obtained. A hemolytic prediction model based on the shear stress is built based on the calculation results, and it can be used for quantitative predictions of the hemolytic behavior of a blood pump. Hemolysis tests in vitro were performed 6 times with fresh bovine blood. At each time, the flow of the pump NIVADIII is 5 L/min and the outflow tract pressure is 100 mmHg. According to the tests, the plasma free hemoglobin (FHB) content and the hematocrit (HCT) are measured after 0 s, 0.5 s, 1 s, 1.5 s, …4 s. At the end of each experiment Normal Index of Hemolysis (NIH) of NIVADIII is calculated. The average of NIH is 0.0055 g/100L, almost identical with that obtained from the hemolytic prediction model. This method can be applied in the selection stage of a blood pump. |
| Databáze: | OpenAIRE |
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