In vivoandin vitropermeability in coeliac disease
| Autor: | Georg Oberhuber, J Wyatt, M. Schwarzenhofer, H. Vogelsang, B. Steiner |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Coeliac disease Lactulose In vivo Internal medicine medicine Ingestion Pharmacology (medical) chemistry.chemical_classification Hepatology biology business.industry Gastroenterology nutritional and metabolic diseases medicine.disease Gluten digestive system diseases In vitro Endocrinology chemistry Immunology biology.protein Mannitol business Gliadin medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 15:1417-1425 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.2001.01034.x |
| Popis: | Background: An increased permeability to sugars is found in the intestine of untreated patients with coeliac disease after oral ingestion. Aim: To test whether in vitro permeability resembles in vivo permeability tests and whether an in vitro gliadin gluten challenge could be performed by an in vitro permeability test. Methods: We measured in vivo (urinary excretion after sucrose–lactulose–mannitol ingestion) and in vitro permeability (by mini-Ussing chambers) in 25 healthy controls, 12 relatives of coeliac disease patients, 19 treated, eight partly treated and 16 untreated patients with coeliac disease. Results: In vivo sugar permeability was increased in nearly all coeliac patients. Additionally, in vitro permeability to lactulose (P=0.0007), mannitol (P=0.004) and sucrose (P=0.042) was higher in untreated patients with coeliac disease. It correlated with in vivo permeability (sucrose τ=0.61, P=0.006; lactulose τ=0.41, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text