Synthesis and Characterization of Fluorescent Silica Nanoparticles Functionalized with Collagens of Variable Lengths
| Autor: | Jianxi Xiao, Shanshan Zhang, Yong Qian, Shenglong Ding, Miaomiao Yuan, Jun Lu, Zaiman Liu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biocompatibility Low toxicity Natural materials Chemistry Nanotechnology General Chemistry 010402 general chemistry 01 natural sciences Fluorescence 0104 chemical sciences Characterization (materials science) law.invention Silica nanoparticles 03 medical and health sciences 030104 developmental biology law Recombinant DNA Cytotoxicity |
| Zdroj: | Chinese Journal of Chemistry. 34:788-794 |
| ISSN: | 1001-604X |
| Popis: | Collagen, the most abundant protein in human body, has been widely used as an excellent natural material for diverse biomedical applications due to its superior properties such as ample biological interaction sites, minimal immunogenicity and high biocompatibility. Collagens of different lengths are produced by recombinant technology and utilized to functionalize fluorescent silica nanoparticles (FNPs). The collagen-functionalized FNPs display mono-disperse distribution, but their sizes are dependent on the length of collagen. These modified FNPs all show nice fluorescence profile as well as low cytotoxicity, suggesting promising applications in bioimaging. We have demonstrated that various types of collagen, conveniently produced by recombinant technology, can be used to modify silica nanoparticles with nice characteristics such as mono-dispersion, non-interference in fluorescence and low toxicity. It may endow fluorescent silica nanoparticles with broad biological applications. |
| Databáze: | OpenAIRE |
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