Supercritical fluid chromatographic separation on preparative scale and in continuous mode
| Autor: | Monika Johannsen, Gerd Brunner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
business.industry Elution General Chemical Engineering 010401 analytical chemistry 02 engineering and technology Continuous mode 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Supercritical fluid 0104 chemical sciences Separation process chemistry.chemical_compound Chromatographic separation chemistry Batch processing Physical and Theoretical Chemistry Simulated moving bed 0210 nano-technology Process engineering business Volatility (chemistry) |
| Zdroj: | The Journal of Supercritical Fluids. 134:61-70 |
| ISSN: | 0896-8446 |
| Popis: | Chromatography with supercritical fluids (SFC) is a powerful tool for carrying out separations of substances with very similar structure and volatility, such as isomers of various kinds. In this contribution, we discuss the separation process aiming at the recovery of products on a much larger scale than analytical. Nevertheless, for developing such a process, the separation is carried out first on analytical scale to determine optimum operating conditions and select stationary phase, mobile phase, and co-solvent (modifier), if necessary. Determination of isotherms is helpful for simulating the separation process. Verification of the separation process includes the recycling of the mobile phase. The chromatographic process can be a batch process in the elution mode, or a continuous process, approximated as simulated moving bed (SMB). The batch SFC process, although using a higher quantity of mobile phase is less cost intensive than the SFC-SMB process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect