Human DNA sequence polymorphisms: New opportunities for drug discovery and customized patient care

Autor:	Kleanthis G. Xanthopoulos, Marek S. Liyanage
Rok vydání:	2000
Předmět:	Genetics Drug discovery Pharmacogenomics Drug Discovery Human genome Single-nucleotide polymorphism Genomics Biology Genome Pharmacogenetics Genetic association
Zdroj:	Drug Development Research. 49:46-53
ISSN:	1098-2299 0272-4391
Popis:	Approximately 1 in every 1,000 bp in the human genome differs between individuals. However, only a fraction of these variations are expected to cause disease phenotypes. Such sequence variations are currently utilized for identification of mutated loci in human populations. Furthermore, genotype-phenotype association studies hold promise as prediction models for drug efficacy and may lead to customized patient care. Collectively, these activities encompass the new field of pharmacogenomics. With the potential to increase commercial value of drugs and reduce R&D costs, pharmacogenomics has taken center stage and is now awaiting approval from its audiences. The next frontier of genomics may very well be the integration of the genome map with the phenotypical characteristics of human populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b4b9369ec8bb93c9f13d09e4a101c2f6 https://doi.org/10.1002/(sici)1098-2299(200001)49:1<46::aid-ddr8>3.0.co Zobrazit plný text záznamu Plný text