Acute platelet response to aneurysmal subarachnoid hemorrhage depends on severity and distribution of bleeding: an observational cohort study
| Autor: | Radosław Rzepliński, Tymon Skadorwa, Kacper Kostyra, Bogusław Kostkiewicz, Mikołaj Sługocki |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Subarachnoid hemorrhage business.industry Thrombogenicity General Medicine medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Intraventricular hemorrhage Interquartile range Internal medicine Cardiology Medicine Surgery Platelet Neurology (clinical) Platelet activation Mean platelet volume business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Neurosurgical Review. 44:2647-2658 |
| ISSN: | 1437-2320 0344-5607 |
| Popis: | Microthrombosis after aneurysmal subarachnoid hemorrhage (aSAH) is considered to initiate neuroinflammation, vessel remodeling, and blood-brain barrier leakage. We aimed to verify the hypothesis that the intensity of thrombogenicity immediately after aSAH depends on the amount and distribution of extravasated blood. This observational cohort study included 37 consecutive aSAH patients admitted no longer than 24 h after ictus. Volumes of subarachnoid and intraventricular hemorrhages as well as the Subarachnoid Hemorrhage Early Brain Edema Scale (SEBES) score were calculated in each case. Platelet system status was described by platelet count (PLT), mean platelet volume (MPV), MPV to PLT ratio, and platelet-large cell ratio (P-LCR). Median hemorrhage volume amounted to 11.4 ml (interquartile range 2.8–26.8 ml). Patients with more severe hemorrhage had lower PLT and higher MPV to PLT ratio (ρ = − 0.49, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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