Engineering aspects of FlowNMR spectroscopy setups for online analysis of solution-phase processes
| Autor: | Ulrich Hintermair, Owen J. Harper, Rachael Broomfield-Tagg, Daniel B. G. Berry, Alejandro Bara-Estaún, Catherine L. Lyall, Asad Saib, Isabel Anna Thomlinson, John P. Lowe |
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| Rok vydání: | 2021 |
| Předmět: |
Fluid Flow and Transfer Processes
010405 organic chemistry Computer science Process Chemistry and Technology media_common.quotation_subject 010402 general chemistry 01 natural sciences Solution phase Catalysis 0104 chemical sciences Variety (cybernetics) Online analysis Chemistry (miscellaneous) Systems engineering Chemical Engineering (miscellaneous) Relevance (information retrieval) Quality (business) Good practice Spectroscopy High magnetic field media_common |
| Zdroj: | Reaction Chemistry & Engineering. 6:1548-1573 |
| ISSN: | 2058-9883 |
| Popis: | Online analysis and monitoring of solution phase chemistry by way of nuclear magnetic resonance spectroscopy on a recirculating sample from an external reaction vessel (FlowNMR) has proven to be a valuable tool for understanding the dynamic behaviour of complex solution-phase systems in real time. A variety of flow cells and setups have been used at both low and high magnetic field strengths for various applications, and the choice of materials, dimensions and components can have a profound impact on the quality and relevance of the data obtained. Here we review some fundamental engineering aspects of FlowNMR setups to help avoid common pitfalls and work towards establishing good practice quality guidelines (GxP) for FlowNMR investigations in academia and industry. |
| Databáze: | OpenAIRE |
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