Evaluation of the cough profile of fosinopril in hypertensive patients with ACE inhibitor-associated cough—A pilot study
| Autor: | Peter E. Pool, F. Wilford Germino, Michael S. Willett, Juan Lastra, Susan Wallace, Dennis Cryer, Bruce Spinowitz, Jacqueline de Silva, William Benjamin Smith, Henry Punzi, Donna J. Mills |
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| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology business.industry Respiratory disease Angiotensin-converting enzyme Essential hypertension medicine.disease Gastroenterology respiratory tract diseases Endocrinology Enzyme inhibitor Internal medicine Cough Frequency Fosinopril ACE inhibitor Toxicity medicine biology.protein Pharmacology (medical) business medicine.drug |
| Zdroj: | Current Therapeutic Research. 54:469-475 |
| ISSN: | 0011-393X |
| DOI: | 10.1016/s0011-393x(05)80665-4 |
| Popis: | To evaluate the cough profile of fosinopril in treated hypertensive patients with active cough associated with angiotensin-converting enzyme (ACE) inhibitors other than fosinopril, a 7-week, prospective, open-label study was undertaken. This consisted of a 1-week treatment with the previous ACE inhibitor, during which ACE inhibitor-associated cough was confirmed, followed by a switch to fosinopril, 10 to 20 mg once daily, for 6 weeks. The cough profiles of 24 men or women with mild to moderate essential hypertension controlled by an ACE inhibitor other than fosinopril, and with active, nonproductive ACE inhibitor-associated cough, were closely monitored. Significant ( P t test) decreases in cough frequency, severity, and index, and significant ( P t test) changes in the characteristics of the cough were observed when patients with ACE inhibitor-associated cough were switched over to fosinopril for 6 weeks. This pilot study has demonstrated a significant improvement in the cough symptom profile of patients who had been actively coughing with other ACE inhibitor therapy when switched to fosinopril, and raises the question as to whether the production of cough may vary among ACE inhibitors. |
| Databáze: | OpenAIRE |
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