Three new sesquiterpene lactones from Carpesium abrotanoides
| Autor: | Chun-Xue Yu, Pei-Qian Wu, Feng-Ming Qi, Yi-Fan Yu, Qiao-Ling Hu, Ying-Hong Liu, Dong-Qing Fei, Zhan-Xin Zhang, Ye Zhao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Human leukemia
Traditional medicine 010405 organic chemistry Plant Science Sesquiterpene 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cancer cell Cytotoxic T cell Carpesium abrotanoides Agronomy and Crop Science Human breast Biotechnology |
| Zdroj: | Phytochemistry Letters. 27:154-159 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2018.07.010 |
| Popis: | Three new sesquiterpene lactones, 5α-hydroxy-4α,15-epoxy-11αH-eudesman-12,8β-olide (1), carabrol-4-O-palmitate (2) and carabrol-4-O-linoleate (3), along with five known ones, were isolated from the whole plant of Carpesium abrotanoides. The structures of new compounds were determined by extensive spectroscopic analysis, and compound 1 was also elucidated by X-ray single-crystal diffraction analysis. The cytotoxic activities of these new compounds against human leukemia cells HL-60 and human breast cancer cells MCF-7 were also evaluated by MTS method. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect