Glucosamine, Chondroitin, and Manganese Ascorbate for Degenerative Joint Disease of the Knee or Low Back: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
Autor: | J C Mosure, P D Kim, A F Philippi, Christopher T. Leffler, S G Leffler |
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Rok vydání: | 1999 |
Předmět: |
medicine.medical_specialty
Visual analogue scale business.industry Public Health Environmental and Occupational Health Chronic pain General Medicine Osteoarthritis medicine.disease Ascorbic acid Placebo Crossover study Low back pain Clinical trials on glucosamine and chondroitin Internal medicine medicine Physical therapy medicine.symptom business |
Zdroj: | Military Medicine. 164:85-91 |
ISSN: | 1930-613X 0026-4075 |
DOI: | 10.1093/milmed/164.2.85 |
Popis: | Objective A 16-week randomized, double-blind, placebo-controlled crossover trial of a combination of glucosamine HCl (1,500 mg/day), chondroitin sulfate (1,200 mg/day), and manganese ascorbate (228 mg/day) in degenerative joint disease (DJD) of the knee or low back was conducted. Methods Thirty-four males from the U.S. Navy diving and special warfare community with chronic pain and radiographic DJD of the knee or low back were randomized. A summary disease score incorporated results of pain and functional questionnaires, physical examination scores, and running times. Changes were presented as a percentage of the patient's average score. Results Knee osteoarthritis symptoms were relieved as demonstrated by the summary disease score (-16.3%; p = 0.05), patient assessment of treatment effect (p = 0.02), visual analog scale for pain recorded at clinic visits (-26.6%; p = 0.05) and in a diary (-28.6%; p = 0.02), and physical examination score (-43.3%; p = 0.01). Running times did not change. The study neither demonstrated, nor excluded, a benefit for spinal DJD. Side effect frequency was similar to that at baseline. There were no hematologic effects. Conclusions The combination therapy relieves symptoms of knee osteoarthritis. A larger data set is needed to determine the value of this therapy for spinal DJD. Short-term combination therapy appears safe in this setting. |
Databáze: | OpenAIRE |
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