Preparation of N-[11C]methyl-2,5-dimethoxy-4-methylamphetamine
| Autor: | A. Blocher, M. Solbach, K. A. Kovar, H. J. Machulla, D. Gündisch |
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| Rok vydání: | 1997 |
| Předmět: |
Health
Toxicology and Mutagenesis 2 5-Dimethoxy-4-methylamphetamine Public Health Environmental and Occupational Health Substrate (chemistry) Pollution Analytical Chemistry Solvent chemistry.chemical_compound Nuclear Energy and Engineering chemistry In vivo Labelling Yield (chemistry) Organic chemistry Radiology Nuclear Medicine and imaging Acetonitrile Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 220:109-111 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02035359 |
| Popis: | In order to evaluate the neurobiological mechanism causing the psychogenic effects of N-methyl-2,5-dimethoxy-4-methylamphetamine (MDOM), the11C labelled analogue was prepared for application in in vivo PET studies by the reaction of 2,5-dimethoxy-4-methylamphetamine (DOM) with [11C]CH3I. The radiochemical yield was determined in dependence on time, temperature, solvent and amount of substrate. The best conditions for fast labelling reactions with11C on a preparative scale were found to be a reaction time of 10 miutes at 110°C using 1 mg DOM in acetonitrile thus obtaining radiochemical yields of 80% (based on produced [11C]CH3I). |
| Databáze: | OpenAIRE |
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