Variable Expression of the V1 Vasopressin Receptor Modulates the Phenotypic Response of Steroid-Secreting Adrenocortical Tumors1
| Autor: | Yves de Keyzer, Véronique Perraudin, Eric Clauser, Jean-Marc Kuhn, Marie-Charles Raux-Demay, Giorgio Arnaldi, Xavier Bertagna, Jean-Pierre Luton, Marie-Laure Raffin-Sanson, Jean-Marie Gasc |
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| Rok vydání: | 1998 |
| Předmět: |
Arginine vasopressin receptor 1B
Vasopressin medicine.medical_specialty Adrenal cortex Endocrinology Diabetes and Metabolism medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Biology medicine.disease Biochemistry Cushing syndrome Steroid hormone Endocrinology medicine.anatomical_structure Internal medicine medicine hormones hormone substitutes and hormone antagonists Glucocorticoid Vasopressin receptor medicine.drug Hydrocortisone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 83:2029-2035 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.83.6.4873 |
| Popis: | We studied the putative role of the vasopressin receptors in the phenotypic response of steroid-secreting adrenocortical tumors. A retrospective analysis of a series of 26 adrenocortical tumors responsible for Cushing’s syndrome (19 adenomas and 7 carcinomas) showed that vasopressin (10 IU, im, lysine vasopressin) induced an ACTH-independent cortisol response (arbitrarily defined as a cortisol rise above baseline of 30 ng/mL or more) in 7 cases (27%). In comparison, 68 of 90 patients with Cushing’s disease (76%) had a positive cortisol response. We then prospectively examined the expression of vasopressin receptor genes in adrenocortical tumors of recently operated patients (20 adenomas and 19 adrenocortical carcinomas). We used highly sensitive and specific quantitative RT-PCR techniques for each of the newly characterized human vasopressin receptors: V1, V2, and V3. The V1 messenger ribonucleic acid (mRNA) was detected in normal adrenal cortex and in all tumors. Its level varied widely between 2.0 × 102... |
| Databáze: | OpenAIRE |
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