Synthesis and calcium antagonistic activity of a series of diethyl benzofuryl, benzothienyl and benzogammapyronyl benzylphosphonates

Autor:	R Bonnafous, Jean-Luc Stigliani, G Baziard-Mouysset, G. Tchani, J Tisne-Versailles, M. Payard
Rok vydání:	1993
Předmět:	Pharmacology Fostedil Bicyclic molecule Chemistry Stereochemistry organic chemicals Organic Chemistry Benzothiophene chemistry.chemical_element Biological activity General Medicine Calcium Phosphonate chemistry.chemical_compound Drug Discovery Chromone heterocyclic compounds Benzofuran
Zdroj:	European Journal of Medicinal Chemistry. 28:539-546
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90084-r
Popis:	In this work we present about 15 original heterocyclic diethyl benzylphosphonate analogues of fostedil, in which we have varied the nature of the heterocycle, the substituents or the phosphonic group, or even the position of this latter. Three diethyl 4-(2-benzofuryl) benzyl phosphonates exhibited slightly higher calcium antagonism than the control. Solely substitution with a fluorine atom was able to maintain activity, whereas the other modifications always decreased it.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b49e95cb4af1d88bedd571d7f6db2a9f https://doi.org/10.1016/0223-5234(93)90084-r Zobrazit plný text záznamu