Toxic Retinopathy induced by Sodium Iodate in Rabbits: Correlation between Electroretinography, Vitamin A levels in Blood, Electronmicroscopic Histology and Colour Fluorescein Angiography

Autor:	Franck Bacin, B. Kantelip, Pierre Tronche, Pierre Sole, Rinaldo Alfieri
Rok vydání:	1978
Předmět:	Vitamin Pathology medicine.medical_specialty medicine.diagnostic_test Chemistry Histology Anatomy Lamellar granule Fluorescein angiography Epithelium chemistry.chemical_compound medicine.anatomical_structure medicine sense organs Fluorescein Sodium iodate Electroretinography
Zdroj:	Documenta Ophthalmologica Proceedings Series ISBN: 9789400999596
DOI:	10.1007/978-94-009-9957-2_19
Popis:	Experimentally induced retinoses are useful in that they give the possibility of studying the pathogenesis of human tapeto-retinal degeneration. Intravenous injections of sodium iodate at 20 mg/kg were chosen to intoxicate rabbits of the “Fauve de Bourgogne” variety. At varying times after the injections, the following were carried out: 1. An electroretinography study: this shows the early disappearance of the e-waves, followed by a change in the b2-wave. 2. A biochemical study: this shows a drop of the vitamin A level in the blood, which happens long after the electroretinographic changes. 3. An electronmicroscopic study: this shows early changes in Bruch’s membrane and the pigment epithelium. 4. A colour fluorescein angiographic study: this shows an abnormal distribution of the fluorescein which probably indicates perturbations in the permeability of the pigment epithelium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b49520014d631b2f7ebcbfd26c42d3e3 https://doi.org/10.1007/978-94-009-9957-2_19 Zobrazit plný text záznamu