Insight into the possible mechanism of antidiarrheal and antispasmodic activities of piperine
| Autor: | Abdul Jabbar Shah, Anwarul Hassan Gilani, Syed Intasar Husain Taqvi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Loperamide Piper Voltage-dependent calcium channel Traditional medicine biology Alkaloid Pharmaceutical Science General Medicine Piperaceae biology.organism_classification chemistry.chemical_compound Complementary and alternative medicine chemistry Piperine Drug Discovery medicine Molecular Medicine Antispasmodic Mode of action medicine.drug |
| Zdroj: | Pharmaceutical Biology. 47:660-664 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1080/13880200902918352 |
| Popis: | Piperine is a piperidine-ring containing alkaloid and a major constituent of Piper nigrum Linn. and Piper longum Linn. species, belonging to the Piperaceae family. The present study explored their mode of action in gastrointestinal disorders, such as diarrhea and colic. Piperine at the dose of 10 mg/kg provided complete protection from castor oil-induced diarrhea in mice, similar to that of loperamide. In isolated rabbit jejunum preparations, piperine exhibited concentration-dependent inhibition of spontaneous contractions with an EC50 value of 149.1 μM (89.26–249.20, 95% CI). When used to treat high K+ (80 mM)-induced sustained contractions, piperine inhibited such contractions with an EC50 value of 80.86 μM (56.10–116.50, 95% CI), which suggested a calcium channel blocking (CCB) effect. The CCB effect was further confirmed when pretreatment of the tissues with piperine (10–100 μM) caused a rightward shift in the Ca++ concentration–response curves (CRCs) in Ca++-free medium, similar to that caused by ver... |
| Databáze: | OpenAIRE |
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